ADC Name	Tubulysin-aMeso ADC (Lysine-conjugated random ADCs)
Synonyms	tubulysin-aMeso ADC (Lysine-conjugated random ADCs)    Click to Show/Hide
Organization	Bristol Myers Squibb.
Drug Status	Investigative
Drug-to-Antibody Ratio	3.6
	3D MOL			2D MOL
Antibody Name	Undisclosed
Antigen Name	Mesothelin (MSLN)					Antigen Info
Payload Name	Undisclosed
Linker Name	Undisclosed
Conjugate Type	Random conjugation through nucleophilic lysines

Standard Type	Value	Units	Description	Reference
Maximum Observed Concentration (Cmax)	5436	ng/mL	PK parameters of three ADCs dosed at 0.5 mg/kg in vivo.	[1]
Area Under the Concentration-Time Curve (AUC)	663	h·ug/mL	PK parameters of three ADCs dosed at 0.5 mg/kg in vivo, AUC0-336h.	[1]

Standard Type	Value	Units	Description	Reference
Elimination Half-Life (t1/2)	205	h	PK parameters of three ADCs dosed at 0.5 mg/kg in vivo.	[1]

Ref 1	The Impact of Conjugation Mode and Site on Tubulysin Antibody-Drug-Conjugate Efficacy and Stability