ADC Name	Hinge-cysteine ADC
Synonyms	tubulysin-aMeso ADC (N297Q ADC)    Click to Show/Hide
Organization	Bristol Myers Squibb.
Drug Status	Investigative
Drug-to-Antibody Ratio	3.8
	3D MOL			2D MOL
Antibody Name	Undisclosed
Antigen Name	Mesothelin (MSLN)					Antigen Info
Payload Name	Undisclosed
Linker Name	Undisclosed
Conjugate Type	Conjugation at hinge cysteine.

Standard Type	Value	Units	Description	Reference
Maximum Observed Concentration (Cmax)	7859	ng/mL	PK parameters of three ADCs dosed at 0.5 mg/kg in vivo.	[1]
Area Under the Concentration-Time Curve (AUC)	809	h·ug/mL	PK parameters of three ADCs dosed at 0.5 mg/kg in vivo, AUC0-336h.	[1]

Standard Type	Value	Units	Description	Reference
Elimination Half-Life (t1/2)	192	h	PK parameters of three ADCs dosed at 0.5 mg/kg in vivo.	[1]

Ref 1	The Impact of Conjugation Mode and Site on Tubulysin Antibody-Drug-Conjugate Efficacy and Stability