Antigen Information

General Information of This Antigen (ID: TAR0ZHRFU)
Antigen Name
Glutamate carboxypeptidase 2 (FOLH1)
Gene Name
FOLH1
Gene ID
2346
Synonym
Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; N-acetylated-alpha-linked acidic dipeptidase I; Prostate-specific membrane antigen; Pteroylpoly-gamma-glutamate carboxypeptidase
Sequence
MWNLLHETDSAVA.RPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKAFL
DELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNK
THPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYART
EDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVKSY
PDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYYDA
QKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTL
RGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFASWD
AEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKELK
SPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWE
TNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAV
VLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLR
MMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPS
KAWGEVKRQIYVAAFTVQAAAETLSEVA

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Family
Peptidase M28 family
Function
Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.; Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

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Uniprot Entry
FOLH1_HUMAN
HGNC ID
HGNC:3788
KEGG ID
hsa:2346
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
38751786 5D3 (CC-MLB8237)3.2 ATC [1]
MLN8237
Undisclosed
NHS-PEG-TCO-Tz
 ADC Info 
5D3 mAb-AF488
 Antibody Info 
ADC Name Payload Target Linker ADC Info
38751786 5D3 (CC-MLB8237)3.2-AF488 [1]
MLN8237
Undisclosed
NHS-PEG-TCO-Tz
 ADC Info 
5D3 mAb-AF555
 Antibody Info 
ADC Name Payload Target Linker ADC Info
38751786 5D3 (CC-MLB8237)3.2-AF555 [1]
MLN8237
Undisclosed
NHS-PEG-TCO-Tz
 ADC Info 
5D3 mAb-CF750
 Antibody Info 
ADC Name Payload Target Linker ADC Info
38751786 5D3 (CC-MLB8237)3.2-CF750 [1]
MLN8237
Undisclosed
NHS-PEG-TCO-Tz
 ADC Info 
ADC Name Payload Target Linker ADC Info
Monoclonal antibody 7E11 C5-selenocystamine conjugate [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
H8-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD7 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H8-LD8 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA -LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA -LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA -LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA -LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA -LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MHB048C [4]
MH30010008
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
Anti-PSMA IgG1 mAb D2B
 Antibody Info 
ADC Name Payload Target Linker ADC Info
111In-DTPA-D2B-DAR4-MMAE [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
111In-DTPA-D2B-DAR2-MMAE [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-PSMA IgG1k mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JNJ-95298177
Amberstatin 269 (AS269)
Microtubule (MT)
Oxime-PEG3
 ADC Info 
Anti-PSMA mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-15 [6]
DM1 derivative 15
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
PSMA-16 [6]
DM1 derivative 16
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
SHR-4394
SHR9265
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-PSMA mAb 5D3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
111In-DOTA-5D3 [7]
Indium-111
Human Deoxyribonucleic acid (hDNA)
Tetraxetan
 ADC Info 
Anti-PSMA mAb D2B
 Antibody Info 
ADC Name Payload Target Linker ADC Info
D2B-DCM [8]
Duocarmycin A
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Cit-PABC
 ADC Info 
Anti-PSMA mAb h3/F11-Var16
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H3/F11-Var16 (Anti-PSMA)-30.2060 [9]
Amanitin 30.206
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
H3/F11-Var16 (Anti-PSMA)-30.2867 [9]
Amanitin 30.2867
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb hD7-1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HD7-1 (VL-VH)-PE40 [10]
Pseudomonas exotoxin PE40
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
HD7-1 (VL-VH)-PE24 [10]
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
HD7-1 (VL-VH)-PE24mut [10]
Pseudomonas exotoxin PE24 mut
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
Anti-PSMA mAb wt
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYD998 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-wt-vcMMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2015177360A1 ADC-wt-mcMMAF [11]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb wt HC A339C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC339 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC D376C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC376 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC E152C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC152 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC G236C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC236 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC P153C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC153 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC P247C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC247 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC S375C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC375 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC S41C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYD1091 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-HC41-vcMMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2015177360A1 ADC-HC41-mcMMAF [11]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb wt HC S41C/S375C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC41-375 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC S41C/T120C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-HC41-120 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt HC T120C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYD1035 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC E165C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC205 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC G157C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC157 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC G41C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC41 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-LC41-vcMMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2015177360A1 ADC-LC41-mcMMAF [11]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb wt LC L154C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC165 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC P40C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC154 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
WO2015177360A1 ADC-LC40-vcMMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
WO2015177360A1 ADC-LC40-mcMMAF [11]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-PSMA mAb wt LC T109C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC109 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA mAb wt LC V205C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015177360A1 ADC-LC40 [11]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Anti-PSMA scFv
 Antibody Info 
ADC Name Payload Target Linker ADC Info
124I-scFvD2B [12]
Iodine I-124
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA-D265C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-PSMA-D265C-30.2060 [9]
Amanitin 30.206
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.2115 [9]
Amanitin 30.2115
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.2347 [9]
Amanitin 30.2347
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.1699 [9]
Amanitin 30.1699
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.2371 [9]
Amanitin 30.2371
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mc-Val-Ala-PABC
 ADC Info 
Anti-PSMA-D265C-30.0880 [9]
Amanitin 30.088
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimido-caproyl
 ADC Info 
Anti-PSMA-D265C-30.2867 [9]
Amanitin 30.2867
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Maleimido-caproyl
 ADC Info 
Anti-PSMA-HC1205
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-HC1205-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC1205-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC1205-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC1205-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC1205-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA-HC41
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-HC41-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD7 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD8 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-HC41-LD9 [3]
Undisclosed
Undisclosed
PSMA-HC41-LD9 LINKER
 ADC Info 
PSMA-HC41-LD10 [3]
Undisclosed
Undisclosed
Trastuzumab-LD1-LINKER
 ADC Info 
PSMA-HC41-LD36 [3]
Seco-DUBA
Human Deoxyribonucleic acid (hDNA)
PSMA-HC41-LD36 LINKER
 ADC Info 
PSMA-HC41-LD64 [3]
PSMA-HC41-LD64 payload
Undisclosed
PSMA-HC41-LD64 LINKER
 ADC Info 
Anti-PSMA-LC40
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-LC40-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC40-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC40-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC40-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC40-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA-LC41
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-LC41-LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC41-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC41-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC41-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA-LC41-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA1 -LD12 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA 1-LD3 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA 1-LD4 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA 1-LD5 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA 1-LD6 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Chimeric Anti-PSMA Antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EP4461318A2 anti-PSMA ADC11 [13]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC12 [13]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC13 [13]
Monomethyl auristatin F
Microtubule (MT)
CLeavable (Val-Citruline-PEG1) linker
 ADC Info 
EP4461318A2 anti-PSMA ADC14 [13]
Monomethyl auristatin F
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
EP4461318A2 anti-PSMA ADC15 [13]
Monomethyl auristatin E
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
ADC Name Payload Target Linker ADC Info
SDV2102 [14]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
Fully human anti-PSMA IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
TD001 [15]
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Humanized Anti-PSMA Antibody Variant 1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EP4461318A2 anti-PSMA ADC1 [13]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC2 [13]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC3 [13]
Monomethyl auristatin F
Microtubule (MT)
CLeavable (Val-Citruline-PEG1) linker
 ADC Info 
EP4461318A2 anti-PSMA ADC4 [13]
Monomethyl auristatin F
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
EP4461318A2 anti-PSMA ADC5 [13]
Monomethyl auristatin E
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
Humanized Anti-PSMA Antibody Variant 2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
EP4461318A2 anti-PSMA ADC6 [13]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC7 [13]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
EP4461318A2 anti-PSMA ADC8 [13]
Monomethyl auristatin F
Microtubule (MT)
CLeavable (Val-Citruline-PEG1) linker
 ADC Info 
EP4461318A2 anti-PSMA ADC9 [13]
Monomethyl auristatin F
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
EP4461318A2 anti-PSMA ADC10 [13]
Monomethyl auristatin E
Microtubule (MT)
Short Cleavable (Valine-Citruline-Acetyl)
 ADC Info 
Humanized anti-PSMA IgG1k mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ARX-517
Amberstatin-269
Undisclosed
Oxime-PEG3
 ADC Info 
ADC Name Payload Target Linker ADC Info
MEDI3726
SG3199 (SC-DR002)
Human deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
YC1613 [16]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Ab-MC-VC-PAB-DMEDA-PEG (N3)-SN38 Linker
 ADC Info 
YC1628 [16]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Ab-MP2-VC-PAB-DMEDA-PEG (N3)-SN38 Linker
 ADC Info 
YC1605 [16]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
YC1667 [16]
MK4827
Undisclosed
Ab-MC-MMAF-VC-PAB-MK4827 Linker
 ADC Info 
YC1663 [16]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Ab-MC-MMAF-VC-PAB-DMEDA-PEG (N3)-SN38 Linker
 ADC Info 
J591 THIOMAB
 Antibody Info 
ADC Name Payload Target Linker ADC Info
J591 DAC [17]
GNE-987 (R)
Bromodomain-containing protein 4 (BRD4)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
J591-SC239C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-D Antibody-Compound (X) [18]
PSMA-D Antibody-Compound (X) payload
Undisclosed
PSMA-D Antibody-Compound (X) linker
 ADC Info 
PSMA-D Antibody-Compound (XI) [18]
PSMA-D Antibody-Compound (XI) payload
Undisclosed
PSMA-D Antibody-Compound (XI) linker
 ADC Info 
PSMA-D Antibody-Compound (XIV) [18]
PSMA-D Antibody-Compound (XIV) payload
Undisclosed
PSMA-D Antibody-Compound (XIV) linker
 ADC Info 
PSMA-D Antibody-Compound (XVIII) [18]
PSMA-D Antibody-Compound (XVIII) payload
Undisclosed
PSMA-D Antibody-Compound (XVIII) linker
 ADC Info 
PSMA-D Antibody-Compound (Ie) [18]
PSMA-D Antibody-Compound (Ie) payload
Undisclosed
PSMA-D Antibody-Compound (Ie) linker
 ADC Info 
PSMA-D Antibody-Compound (XIX) [18]
PSMA-D Antibody-Compound (XIX) payload
Undisclosed
PSMA-D Antibody-Compound (XIX) linker
 ADC Info 
PSMA-D Antibody-Compound (Ii) [18]
PSMA-D Antibody-Compound (Ii) payload
Undisclosed
PSMA-D Antibody-Compound (Ii) linker
 ADC Info 
PSMA-D Antibody-Compound (XLI) [18]
PSMA-D Antibody-Compound (XLI) payload
Undisclosed
PSMA-D Antibody-Compound (XLI) linker
 ADC Info 
PSMA-D Antibody-Compound (XVI) [18]
PSMA-D Antibody-Compound (XIX) payload
Undisclosed
PSMA-D Antibody-Compound (XIX) linker
 ADC Info 
PSMA-D Antibody-Compound (XL) [18]
PSMA-D Antibody-Compound (XL) payload
Undisclosed
PSMA-D Antibody-Compound (XL) linker
 ADC Info 
PSMA-D Antibody-Compound (XLIII) [18]
PSMA-D Antibody-Compound (XLIII) payload
Undisclosed
PSMA-D Antibody-Compound (XLIII) linker
 ADC Info 
PSMA-D Antibody-Compound (XLII) [18]
PSMA-D Antibody-Compound (XLII) payload
Undisclosed
PSMA-D Antibody-Compound (XLII) linker
 ADC Info 
J591-SC239C-Compound (XV) [18]
J591-SC239C-Compound (XV) payload
Undisclosed
J591-SC239C-Compound (XV) linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
MLN2704
DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
PSMA-A Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-A Antibody-Compound (X) [18]
PSMA-A Antibody-Compound (X) payload
Undisclosed
PSMA-A Antibody-Compound (X) linker
 ADC Info 
PSMA-A Antibody-Compound (XI) [18]
PSMA-A Antibody-Compound (XI) payload
Undisclosed
PSMA-A Antibody-Compound (XI) linker
 ADC Info 
PSMA-A Antibody-Compound (XIV) [18]
PSMA-A Antibody-Compound (XIV) payload
Undisclosed
PSMA-A Antibody-Compound (XIV) linker
 ADC Info 
PSMA-A Antibody-Compound (XVIII) [18]
PSMA-A Antibody-Compound (XVIII) payload
Undisclosed
PSMA-A Antibody-Compound (XVIII) linker
 ADC Info 
PSMA-A Antibody-Compound (Ie) [18]
PSMA-A Antibody-Compound (Ie) payload
Undisclosed
PSMA-A Antibody-Compound (Ie) linker
 ADC Info 
PSMA-A Antibody-Compound (XIX) [18]
PSMA-A Antibody-Compound (XIX) payload
Undisclosed
PSMA-A Antibody-Compound (XIX) linker
 ADC Info 
PSMA-A Antibody-Compound (Ii) [18]
PSMA-A Antibody-Compound (Ii) payload
Undisclosed
PSMA-A Antibody-Compound (Ii) linker
 ADC Info 
PSMA-A Antibody-Compound (XLI) [18]
PSMA-A Antibody-Compound (XLI) payload
Undisclosed
PSMA-A Antibody-Compound (XLI) linker
 ADC Info 
PSMA-A Antibody-Compound (XVI) [18]
PSMA-A Antibody-Compound (XIX) payload
Undisclosed
PSMA-A Antibody-Compound (XIX) linker
 ADC Info 
PSMA-A Antibody-Compound (XL) [18]
PSMA-A Antibody-Compound (XL) payload
Undisclosed
PSMA-A Antibody-Compound (XL) linker
 ADC Info 
PSMA-A Antibody-Compound (XLIII) [18]
PSMA-A Antibody-Compound (XLIII) payload
Undisclosed
PSMA-A Antibody-Compound (XLIII) linker
 ADC Info 
PSMA-A Antibody-Compound (XLII) [18]
PSMA-A Antibody-Compound (XLII) payload
Undisclosed
PSMA-A Antibody-Compound (XLII) linker
 ADC Info 
PSMA-A Antibody-Compound (XV) [18]
PSMA-A Antibody-Compound (XV) payload
Undisclosed
PSMA-A Antibody-Compound (XV) linker
 ADC Info 
PSMA-B Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-B Antibody-Compound (X) [18]
PSMA-B Antibody-Compound (X) payload
Undisclosed
PSMA-B Antibody-Compound (X) linker
 ADC Info 
PSMA-B Antibody-Compound (XI) [18]
PSMA-B Antibody-Compound (XI) payload
Undisclosed
PSMA-B Antibody-Compound (XI) linker
 ADC Info 
PSMA-B Antibody-Compound (XIV) [18]
PSMA-B Antibody-Compound (XIV) payload
Undisclosed
PSMA-B Antibody-Compound (XIV) linker
 ADC Info 
PSMA-B Antibody-Compound (XVIII) [18]
PSMA-B Antibody-Compound (XVIII) payload
Undisclosed
PSMA-B Antibody-Compound (XVIII) linker
 ADC Info 
PSMA-B Antibody-Compound (Ie) [18]
PSMA-B Antibody-Compound (Ie) payload
Undisclosed
PSMA-B Antibody-Compound (Ie) linker
 ADC Info 
PSMA-B Antibody-Compound (XIX) [18]
PSMA-B Antibody-Compound (XIX) payload
Undisclosed
PSMA-B Antibody-Compound (XIX) linker
 ADC Info 
PSMA-B Antibody-Compound (Ii) [18]
PSMA-B Antibody-Compound (Ii) payload
Undisclosed
PSMA-B Antibody-Compound (Ii) linker
 ADC Info 
PSMA-B Antibody-Compound (XLI) [18]
PSMA-B Antibody-Compound (XLI) payload
Undisclosed
PSMA-B Antibody-Compound (XLI) linker
 ADC Info 
PSMA-B Antibody-Compound (XVI) [18]
PSMA-B Antibody-Compound (XIX) payload
Undisclosed
PSMA-B Antibody-Compound (XIX) linker
 ADC Info 
PSMA-B Antibody-Compound (XL) [18]
PSMA-B Antibody-Compound (XL) payload
Undisclosed
PSMA-B Antibody-Compound (XL) linker
 ADC Info 
PSMA-B Antibody-Compound (XLIII) [18]
PSMA-B Antibody-Compound (XLIII) payload
Undisclosed
PSMA-B Antibody-Compound (XLIII) linker
 ADC Info 
PSMA-B Antibody-Compound (XLII) [18]
PSMA-B Antibody-Compound (XLII) payload
Undisclosed
PSMA-B Antibody-Compound (XLII) linker
 ADC Info 
PSMA-B Antibody-Compound (XV) [18]
PSMA-B Antibody-Compound (XV) payload
Undisclosed
PSMA-B Antibody-Compound (XV) linker
 ADC Info 
PSMA-C Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PSMA-C Antibody-Compound (X) [18]
PSMA-C Antibody-Compound (X) payload
Undisclosed
PSMA-C Antibody-Compound (X) linker
 ADC Info 
PSMA-C Antibody-Compound (XI) [18]
PSMA-C Antibody-Compound (XI) payload
Undisclosed
PSMA-C Antibody-Compound (XI) linker
 ADC Info 
PSMA-C Antibody-Compound (XIV) [18]
PSMA-C Antibody-Compound (XIV) payload
Undisclosed
PSMA-C Antibody-Compound (XIV) linker
 ADC Info 
PSMA-C Antibody-Compound (XVIII) [18]
PSMA-C Antibody-Compound (XVIII) payload
Undisclosed
PSMA-C Antibody-Compound (XVIII) linker
 ADC Info 
PSMA-C Antibody-Compound (Ie) [18]
PSMA-C Antibody-Compound (Ie) payload
Undisclosed
PSMA-C Antibody-Compound (Ie) linker
 ADC Info 
PSMA-C Antibody-Compound (XIX) [18]
PSMA-C Antibody-Compound (XIX) payload
Undisclosed
PSMA-C Antibody-Compound (XIX) linker
 ADC Info 
PSMA-C Antibody-Compound (Ii) [18]
PSMA-C Antibody-Compound (Ii) payload
Undisclosed
PSMA-C Antibody-Compound (Ii) linker
 ADC Info 
PSMA-C Antibody-Compound (XLI) [18]
PSMA-C Antibody-Compound (XLI) payload
Undisclosed
PSMA-C Antibody-Compound (XLI) linker
 ADC Info 
PSMA-C Antibody-Compound (XVI) [18]
PSMA-C Antibody-Compound (XIX) payload
Undisclosed
PSMA-C Antibody-Compound (XIX) linker
 ADC Info 
PSMA-C Antibody-Compound (XL) [18]
PSMA-C Antibody-Compound (XL) payload
Undisclosed
PSMA-C Antibody-Compound (XL) linker
 ADC Info 
PSMA-C Antibody-Compound (XLIII) [18]
PSMA-C Antibody-Compound (XLIII) payload
Undisclosed
PSMA-C Antibody-Compound (XLIII) linker
 ADC Info 
PSMA-C Antibody-Compound (XLII) [18]
PSMA-C Antibody-Compound (XLII) payload
Undisclosed
PSMA-C Antibody-Compound (XLII) linker
 ADC Info 
PSMA-C Antibody-Compound (XV) [18]
PSMA-C Antibody-Compound (XV) payload
Undisclosed
PSMA-C Antibody-Compound (XV) linker
 ADC Info 
Rosopatamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Rosopatamab tetraxetan [19]
Y90 (Radioactive isotope)
Undisclosed
Tetraxetan
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-PSMA antibody-drug conjugate (Protanbio) [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
PSMA ADC (Jiangsu hengrui) [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-PSMA antibody-deBouganin fusion protein (Crescendo/Sesen Bio) [22]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HDP-103 [23]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Undisclosed
 ADC Info 
DAN-405 [24]
Cabazitaxel
Microtubule (MT)
Undisclosed
 ADC Info 
MMAE.VC.SA.617 [25]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-PSMA antibody-drug conjugate [26]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CB-108 [27]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot41 [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot42 [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot55 [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024118785A3 Lot75 [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Development and therapeutic evaluation of 5D3(CC-MLN8237)(3.2) antibody-theranostic conjugates for PSMA-positive prostate cancer therapy
Ref 2 Monoclonal antibody 7E11 C5-selenocystamine conjugate; 29 Apr 2002.
Ref 3 Non-linear self-immolative linkers and conjugates thereof
Ref 4 Preclinical development of MHB048C: A novel anti-PSMA ADC with a potent topoisomerase I inhibitor
Ref 5 Characterization of Site-Specifically Conjugated Monomethyl Auristatin E- and Duocarmycin-Based Anti-PSMA Antibody-Drug Conjugates for Treatment of PSMA-Expressing Tumors. J Nucl Med. 2018 Mar;59(3):494-501. doi: 10.2967/jnumed.117.196279. Epub 2017 Nov 16.
Ref 6 Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.
Ref 7 Evaluation of 111In-DOTA-5D3, a Surrogate SPECT Imaging Agent for Radioimmunotherapy of Prostate-Specific Membrane Antigen. J Nucl Med. 2019 Mar;60(3):400-406. doi: 10.2967/jnumed.118.214403. Epub 2018 Sep 20.
Ref 8 Duocarmycin-based antibody-drug conjugates as an emerging biotherapeutic entity for targeted cancer therapy: Pharmaceutical strategy and clinical progress. Drug Discov Today. 2021 Aug;26(8):1857-1874. doi: 10.1016/j.drudis.2021.06.012. Epub 2021 Jul 3.
Ref 9 Amatoxin antibody-drug conjugates and uses thereof; 2020-10-29.
Ref 10 In Vitro Evaluation of Humanized/De-immunized Anti-PSMA Immunotoxins for the Treatment of Prostate Cancer. Anticancer Res. 2018 Jan;38(1):61-69. doi: 10.21873/anticanres.12192.
Ref 11 Site-specific conjugation of linker drugs to antibodies and resulting adcs.
Ref 12 Anti-PSMA (124)I-scFvD2B as a new immuno-PET tool for prostate cancer: preclinical proof of principle. J Exp Clin Cancer Res. 2019 Jul 23;38(1):326. doi: 10.1186/s13046-019-1325-6.
Ref 13 Novel anti-prostate-specific membrane antigen (PSMA) antibody drug conjugates
Ref 14 Preclinical evaluation of SDV2102, a novel PSMA-targeting DAR1 ADC for mCRPC treatment
Ref 15 Improved tumor penetration and cytotoxic payload release with TD001, a novel PSMA-targeting ADC with optimized linker-payload composition, in PSMA-expressing CRPC CDX castrated mouse models
Ref 16 Anti-PSMA antibody-drug conjugates and their preparation methods and applications
Ref 17 In Silico-Driven THIOMAB Approach for Stable PROTAC Conjugates by Docking Payloads in Antibody Cavities
Ref 18 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 19 ADC review ROSOPATAMAB TETRAXETAN
Ref 20 Introduction to basic information on anti PRLR anti-PSMA antibody-drug conjugate(Protanbio).
Ref 21 Introduction to basic information on ADC drug PSMA ADC (Jiangsu hengrui)
Ref 22 Engineering and characterization of anti-PSMA humabody-deBouganin fusion proteins. Cancer Res (2018) 78 (13_Supplement): 5770.
Ref 23 Heidelberg pharma product pipeline
Ref 24 Dantari biotechnology company product pipeline
Ref 25 Old Drug, New Delivery Strategy: MMAE Repackaged. Int J Mol Sci. 2023 May 10;24(10):8543. doi: 10.3390/ijms24108543.
Ref 26 Introduction to basic information on ADC drug Anti-PSMA antibody-drug conjugates(Medarex)
Ref 27 Multifunctional biologics for targeted T-cell therapy based on in vivo matured fully human VH domains. Cancer Res (2018) 78 (13_Supplement): 5766.
Ref 28 TLR7 agonists and antibody-drug conjugates thereof