Antigen Information

General Information of This Antigen (ID: TAR0UDQEU)
Antigen Name
Claudin-6 (CLDN6)
Gene Name
CLDN6
Gene ID
9074
Synonym
Skullin
Sequence
MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG
QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLT
SGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGL
LCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV

    Click to Show/Hide
Family
Chondroitin N-acetylgalactosaminyltransferase family
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.

    Click to Show/Hide
Uniprot Entry
CLD6_HUMAN
HGNC ID
HGNC:2048
KEGG ID
hsa:9074
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CLDN (H1L3)- (MSG1-N3)2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7615189B2 ADC42 [1]
JP7615189B2+ADC41+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC43 [1]
JP7615189B2+ADC43+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC44 [1]
JP7615189B2+ADC44+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC45 [1]
JP7615189B2+ADC45+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC46 [1]
JP7615189B2+ADC46+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC47 [1]
JP7615189B2+ADC47+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC48 [1]
JP7615189B2+ADC48+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC49 [1]
JP7615189B2+ADC40+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
Anti-CLDN6 (H1L1) - (MSG1-N3)2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7615189B2 ADC40 [1]
JP7615189B2+ADC40+payload
Undisclosed
JP7615189B2+ADC40+Linker
 ADC Info 
Anti-CLDN6 (H2L2)- (MSGI-N3)2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7615189B2 ADC41 [1]
JP7615189B2+ADC41+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
Anti-CLDN6 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DS-9606a
PBD dimer
Human deoxyribonucleic acid (hDNA)
A cleavable linker
 ADC Info 
AT-03 [2]
TCS132 (AxcynDOT)
Human deoxyribonucleic acid (hDNA)
A cleavable linker
 ADC Info 
QLS5132 [3]
QLS6916
Human deoxyribonucleic acid (hDNA)
A cleavable linker
 ADC Info 
anti-hCLDN6 antibody Ab1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US20250025567A1 ExL1A1 [4]
5-[ (4-{[ (2S)-2- (fluoromethyl)piperazin-1-yl]methyl}-2-methoxyphenyl)methyl|]-N4-pentyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-diamine
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
3-Maleimidopropionic acid linker
 ADC Info 
US20250025567A1 ExL5A1 [4]
US20250025567A1, ExlL5A1, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Ethylmaleimide linker
 ADC Info 
US20250025567A1 ExL7A1 [4]
US20250025567A1, ExlL7A1, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
3-Maleimidopropionic acid linker
 ADC Info 
US20250025567A1 ExL9A1 [4]
US20250025567A1, ExlL7A1, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
3-Maleimidopropionic acid linker
 ADC Info 
anti-hCLDN6 antibody Ab2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US20250025567A1 ExL1A2 [4]
Undisclosed
Undisclosed
3-Maleimidopropionic acid linker
 ADC Info 
GB7008-01
 Antibody Info 
ADC Name Payload Target Linker ADC Info
GB7008-01-Val-Cit-MMAE [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
IMAB027-Val-Cit-MMAE [6]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Ixotatug vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
PLB-002-ab7
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PLB-002 [7]
Eribulin
Microtubule (MT)
A cleavable linker
 ADC Info 
Trastuzumab- (MSG1-N3)2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7615189B2 ADC21 [1]
JP7615189B2+ADC21+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC22 [1]
JP7615189B2+ADC22+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC23 [1]
JP7615189B2+ADC23+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC24 [1]
JP7615189B2+ADC24+payload
Undisclosed
JP7615189B2+ADC24+Linker
 ADC Info 
JP7615189B2 ADC25 [1]
JP7615189B2+ADC23+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC26 [1]
JP7615189B2+ADC26+payload
Undisclosed
JP7615189B2+ADC24+Linker
 ADC Info 
JP7615189B2 ADC27 [1]
JP7615189B2+ADC27+payload
Undisclosed
JP7615189B2+ADC27+Linker
 ADC Info 
JP7615189B2 ADC28 [1]
JP7615189B2+ADC28+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC29 [1]
JP7615189B2+ADC29+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC30 [1]
JP7615189B2+ADC30+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC31 [1]
JP7615189B2+ADC31+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC32 [1]
JP7615189B2+ADC32+payload
Undisclosed
JP7615189B2+ADC32+Linker
 ADC Info 
JP7615189B2 ADC33 [1]
JP7615189B2+ADC33+payload
Undisclosed
JP7615189B2+ADC32+Linker
 ADC Info 
JP7615189B2 ADC34 [1]
JP7615189B2+ADC34+payload
Undisclosed
JP7615189B2+ADC34+Linker
 ADC Info 
JP7615189B2 ADC35 [1]
JP7615189B2+ADC34+payload
Undisclosed
JP7615189B2+ADC35+Linker
 ADC Info 
JP7615189B2 ADC36 [1]
JP7615189B2+ADC35+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC37 [1]
JP7615189B2+ADC34+payload
Undisclosed
JP7615189B2+ADC37+Linker
 ADC Info 
JP7615189B2 ADC38 [1]
JP7615189B2+ADC38+payload
Undisclosed
JP7615189B2+ADC38+Linker
 ADC Info 
JP7615189B2 ADC39 [1]
JP7615189B2+ADC39+payload
Undisclosed
JP7615189B2+ADC39+Linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AT65474 [8]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADCT-242 [9]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024043319A1 81 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7615189B2 ADC1 [1]
JP7615189B2+ADC1+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC2 [1]
JP7615189B2+ADC2+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC3 [1]
JP7615189B2+ADC3+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC4 [1]
JP7615189B2+ADC4+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC5 [1]
JP7615189B2+ADC5+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC6 [1]
JP7615189B2+ADC6+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC7 [1]
JP7615189B2+ADC7+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC8 [1]
JP7615189B2+ADC8+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC9 [1]
JP7615189B2+ADC9+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC10 [1]
JP7615189B2+ADC10+payload
Undisclosed
JP7615189B2+ADC10+Linker
 ADC Info 
JP7615189B2 ADC11 [1]
JP7615189B2+ADC11+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC12 [1]
JP7615189B2+ADC12+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC13 [1]
JP7615189B2+ADC13+payload
Undisclosed
JP7615189B2+ADC13+Linker
 ADC Info 
JP7615189B2 ADC14 [1]
JP7615189B2+ADC14+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC15 [1]
JP7615189B2+ADC9+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC16 [1]
JP7615189B2+ADC16+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC17 [1]
JP7615189B2+ADC16+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2ADC18 [1]
JP7615189B2+ADC18+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC19 [1]
JP7615189B2+ADC19+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC20 [1]
Undisclosed
Undisclosed
JP7615189B2+ADC20+Linker
 ADC Info 
References
Ref 1 Antibody-pyrrolobenzodiazepine derivative conjugates
Ref 2 Axcynsis therapeutics product pipeline
Ref 3 QLS5132, a highly selective anti-CLDN6 ADC with broader therapeutic window
Ref 4 Antibody-drug complex containing Toll-like receptor 7/8 dual agonist compound
Ref 5 Introduction to basic information on ADC drug GB-7008-01-vcMMAE.
Ref 6 Preclinical characterization of the safety and antitumor activity of IMAB027-vcMMAE, an anticlaudin 6 antibody-drug conjugate. Cancer Res (2018) 78 (13_Supplement): 1778.
Ref 7 PLB-002 is a novel Claudin 6 antibody-drug conjugate for ovarian cancer and testicular germ cell cancer
Ref 8 AT65474, a highly selective anti-CLDN6 ADC with a proprietary payload
Ref 9 Preclinical investigation of ADCT-242, a novel exatecan-based antibody drug conjugate targeting Claudin-6, as single agent or in combination in ovarian and non-small lung cancer models
Ref 10 Antibody-drug complexes