Antigen Information

General Information of This Antigen (ID: TAR0TXBRL)
Antigen Name
C-C chemokine receptor type 4 (CCR4)
Gene Name
CCR4
Gene ID
1233
Synonym
CMKBR4; K5-5; CD194
Sequence
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL

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Family
G-protein coupled receptor 1 family
Function
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

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Uniprot Entry
CCR4_HUMAN
HGNC ID
HGNC:1605
KEGG ID
hsa:1233
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
CCR4-IL2 IT [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
IL2-CCR4 IT [2]
IL2 fusion toxin
Interleukin-2 receptor subunit alpha (IL2RA)
Undisclosed
 ADC Info 
IL2-CCR4 immunotoxin [2]
IL2 fusion toxin
Interleukin-2 receptor subunit alpha (IL2RA)
Undisclosed
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IL2 IT [2]
IL2 fusion toxin
Interleukin-2 receptor subunit alpha (IL2RA)
Undisclosed
 ADC Info 
CCR4 IT [2]
IL2 fusion toxin
Interleukin-2 receptor subunit alpha (IL2RA)
Undisclosed
 ADC Info 
References
Ref 1 CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model. FEBS Open Bio. 2023 Jul;13(7):1309-1319. doi: 10.1002/2211-5463.13625. Epub 2023 May 15.
Ref 2 Bispecific human IL2-CCR4 immunotoxin targets human cutaneous T-cell lymphoma. Mol Oncol. 2020 May;14(5):991-1000. doi: 10.1002/1878-0261.12653. Epub 2020 Mar 13.