Antigen Information

General Information of This Antigen (ID: TAR0JMGXV)
Antigen Name
Membrane cofactor protein (CD46)
Gene Name
CD46
Gene ID
4179
Synonym
MCP; MIC10; TLX;Trophoblast leukocyte common antigen;CD46
Sequence
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS
VSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAV
ICVVPYRYLQRRKKKGTYLTDETHREVKFTSL

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Function
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

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Uniprot Entry
MCP_HUMAN
HGNC ID
HGNC:6953
KEGG ID
hsa:4179
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CD46 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
T2LD6 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-gucuronide-PEG8-PABC
 ADC Info 
T2LD5 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-glucuronide-PABC
 ADC Info 
T2LD4 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-glucuronidase cleavable linker
 ADC Info 
T2LD3 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8
 ADC Info 
T2LD2 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-acetic acid
 ADC Info 
T2LD1 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-PABC
 ADC Info 
HCD46-19 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Hydrophilic cleavable linker 19
 ADC Info 
HCD46-25 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Alternative linker without basic amines linker 25
 ADC Info 
HCD46-26 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Maleimide based noncleavable linker 26
 ADC Info 
HCD46-29 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
PNU-thiazole cleavable linker 29
 ADC Info 
Anti-CD46 mAb 23AG2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD46-ADC [3]
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
FOR46
Monomethyl auristatin E
Microtubule (MT)
A cleavable linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD46 antibody-drug conjugate [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD46-antibody drug conjugate (AbbVie) [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD46 CAB-ADC [6]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CD46-ADC [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2107042118. doi: 10.1073/pnas.2107042118.
Ref 2 Evaluation of PNU-159682 antibody drug conjugates (ADCs). Bioorg Med Chem Lett. 2020 Dec 15;30(24):127640. doi: 10.1016/j.bmcl.2020.127640. Epub 2020 Oct 28.
Ref 3 Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 Dec 1;126(12):4640-4653. doi: 10.1172/JCI85856. Epub 2016 Nov 14.
Ref 4 Introduction to basic information on anti-CD46 antibody-drug conjugate(University of California San Francisco/Washington University in St Louis).
Ref 5 Introduction to basic information on anti-CD46- antibody drug conjugates(AbbVie).
Ref 6 Conditionally active biologics (CAB): A novel class of molecules targeting solid tumors. Cancer Res (2020) 80 (16_Supplement): 4560.
Ref 7 CD46-ADC Reduces the Engraftment of Multiple Myeloma Patient-Derived Xenografts