Antigen Information

General Information of This Antigen (ID: TAR0IFMJZ)
Antigen Name
Melanotransferrin (MELTF)
Gene Name
MELTF
Gene ID
4241
Synonym
MAP97; MFI2; Melanoma-associated antigen p97;CD228
Sequence
MRGPSGALWLLLALRTVLGGMEVRWCATSDPEQHKCGNMSEAFREAGIQPSLLCVRGTSA
DHCVQLIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSYYAVAVVRRSSHVT
IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSDYFGGSCVPGAGETS
YSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTVLENTDGKT
LPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLIFRLLNEGQ
RLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLCDPN
RLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQHCMERIQAEQVDAVTL
SGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDELRGKRSCHAGF
GSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALCVGDEQ
GRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE
LLCPNGARAEVSQFAACNLAQIPPHAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFKM
FDSSNYHGQDLLFKDATVRAVPVGEKTTYRGWLGLDYVAALEGMSSQQCSGAAAPAPGAP
LLPLLLPALAARLLPPAL

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Family
Transferrin family
Function
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

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Uniprot Entry
TRFM_HUMAN
HGNC ID
HGNC:7037
KEGG ID
hsa:4241
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-CD228 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BA1302
Monomethyl auristatin E
Microtubule (MT)
MC-β-Ala-(glucuronide)-PABC
 ADC Info 
Biolegend (#363101)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Biolegend (#363101)-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
Chimeric L49
 Antibody Info 
ADC Name Payload Target Linker ADC Info
cL49-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
ADC Name Payload Target Linker ADC Info
SGN-CD228A
Monomethyl auristatin E
Microtubule (MT)
Mal PEG12 based β-glucuronide linker
 ADC Info 
PF-08046031 [2]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hL49-HALC
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49-HALC-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
hL49-HALC-AuristatinT [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49-HALC-TubulysinM [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49-HALC-LipophilicMMAF [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49-HALC-PBD [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49-HALC-MC-VC-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hL49-HALC-MDpr-gluc-MMAE [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
hL49_27D_Ala
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_27D_Ala-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_27D_Gln
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_27D_Gln-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_27D_Tyr
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_27D_Tyr-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_34_Ala
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_34_Ala-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_34_Gln
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_34_Gln-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_34_Tyr
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_34_Tyr-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_3x_Ala
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_3x_Ala-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_3x_Gln
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_3x_Gln-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
hL49_3x_Tyr
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49_3x_Tyr-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
hIgG-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
Humanized Anti-CD228 SGN-CD228A mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
hL49-ADC [3]
Monomethyl auristatin E
Microtubule (MT)
mp-dLAE-PABC
 ADC Info 
mouse L235
 Antibody Info 
ADC Name Payload Target Linker ADC Info
mL235-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
mouse L49
 Antibody Info 
ADC Name Payload Target Linker ADC Info
mL49-MDpr-PEG (12)gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
R&D (#893416)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
R&D (#893416)-MDpr-PEG (12)-gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
Santa Cruz (#271633)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Santa Cruz (#271633)-MDpr-PEG (12)gluc-MMAE [1]
Monomethyl auristatin E
Microtubule (MT)
MDpr-PEG (12)gluc
 ADC Info 
References
Ref 1 Anti-CD228 antibodies and antibody-drug conjugates
Ref 2 PF-08046031: A promising first-in-class antibody-drug conjugate for targeting novel tumor antigen in melanoma
Ref 3 Anti-cd228 antibodies and antibody-drug conjugates; 2022-02-10.