Antigen Information

General Information of This Antigen (ID: TAR0HSEFL)
Antigen Name
Transmembrane 4 L6 family member 1 (TM4SF1)
Gene Name
TM4SF1
Gene ID
4071
Synonym
M3S1; TAAL6; Membrane component chromosome 3 surface marker 1;Tumor-associated antigen L6
Sequence
MCYGKCARCIGHSLVGLALLCIAANILLYFPNGETKYASENHLSRFVWFFSGIVGGGLLM
LLPAFVFIGLEQDDCCGCCGHENCGKRCAMLSSVLAALIGIAGSGYCVIVAALGLAEGPL
CLDSLGQWNYTFASTEGQYLLDTSTWSECTEPKHIVEWNVSLFSILLALGGIEFILCLIQ
VINGVLGGICGFCCSHQQQYDC

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Family
Interleukin-1 receptor family
Uniprot Entry
T4S1_HUMAN
HGNC ID
HGNC:11853
KEGG ID
hsa:4071
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-TM4SF1 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AGX101
Maytansine derivative
Microtubule (MT)
A non-cleavable linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US20240166759A1 Antibody1-L1 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody1-L2 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody1-L3 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody1-L4 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody1-L5 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody1-L6 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody1-L7 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody2-L1 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody2-L2 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody2-L3 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody2-L4 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody2-L5 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody2-L6 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20240166759A1 Antibody2-L7 [1]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IgG2a-PEG8-MMAE [2]
Monomethyl auristatin E
Microtubule (MT)
WO2024102603A1+lgG2a-PEG8-MMAE+Linker
 ADC Info 
BA-PEG4-N-methyl-alanine-Medandine [1]
Medandine
Undisclosed
Undisclosed
 ADC Info 
BA-PEG4-AHX-N-methyl-alanine-Medandine [1]
Medandine
Undisclosed
Undisclosed
 ADC Info 
BA-glucuronidin-N-methyl-alanine-Medandine [1]
Medandine
Undisclosed
Undisclosed
 ADC Info 
BA-Glu- (O-T-butyl) -glucuronoside - N-methyl-alanine - N-methyl-alanine - Medendine [1]
Medandine
Undisclosed
Undisclosed
 ADC Info 
BA-PEG4-D-Glu-0T-Butyl-AHX-N-methyl-alanine-Medandine [1]
Medandine
Undisclosed
Undisclosed
 ADC Info 
BA-PEG4-D-GLU-AHX-N-methyl-alanine-Medandine [1]
Medandine
Undisclosed
Undisclosed
 ADC Info 
BA-PEG4-D-GLU-N-methyl-alanine-Medandine [1]
Medandine
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Combinations comprising anti-TM4SF1 antibodies and immunotherapeutic agents and methods of using the same
Ref 2 Bisecting-glycan bridged conjugation for producing glycoprotein conjugates